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Derek M Yellon Selected Research

Caspase 1 (ICE Protease)

1/2019Role of Caspase 1 in Ischemia/Reperfusion Injury of the Myocardium.
1/2018The Caspase 1 Inhibitor VX-765 Protects the Isolated Rat Heart via the RISK Pathway.

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Derek M Yellon Research Topics

Disease

72Reperfusion Injury
11/2023 - 10/2002
62Infarction (Infarctions)
12/2022 - 06/2002
56Myocardial Infarction
11/2023 - 03/2003
31Ischemia
02/2016 - 08/2002
19ST Elevation Myocardial Infarction
01/2023 - 10/2011
18Myocardial Ischemia (Ischemic Heart Diseases)
11/2023 - 01/2005
10Heart Failure
01/2023 - 12/2007
8Hypoxia (Hypoxemia)
01/2017 - 07/2005
6Neoplasms (Cancer)
11/2023 - 02/2016
6Cardiovascular Diseases (Cardiovascular Disease)
01/2023 - 04/2009
6Acute Kidney Injury (Acute Renal Failure)
08/2017 - 12/2010
6Myocardial Reperfusion Injury
03/2016 - 09/2003
5Cardiotoxicity
11/2023 - 11/2009
5Type 2 Diabetes Mellitus (MODY)
01/2022 - 05/2009
4COVID-19
11/2022 - 01/2021
4Atherosclerosis
11/2020 - 09/2009
4Necrosis
01/2020 - 10/2002
4Obesity
05/2012 - 04/2009
4Contracture
05/2008 - 12/2003
3Acute Coronary Syndrome
10/2022 - 12/2011
3Ischemic Stroke
01/2021 - 12/2019
3Rupture
11/2020 - 01/2019
3Heart Diseases (Heart Disease)
01/2018 - 01/2009
3Stroke (Strokes)
02/2017 - 05/2012
3Coronary Artery Disease (Coronary Atherosclerosis)
05/2013 - 01/2011
3Coronary Disease (Coronary Heart Disease)
04/2009 - 04/2003
2Inflammation (Inflammations)
01/2021 - 01/2020
2Cardiomyopathies (Cardiomyopathy)
01/2017 - 09/2011
2Hemorrhage
01/2017 - 10/2016
2Metabolic Diseases (Metabolic Disease)
02/2016 - 02/2011
2Hypertension (High Blood Pressure)
05/2012 - 08/2007
2Acidosis
08/2010 - 09/2007
2Body Weight (Weight, Body)
11/2009 - 01/2007

Drug/Important Bio-Agent (IBA)

27Phosphotransferases (Kinase)IBA
01/2023 - 02/2003
15Mitochondrial Permeability Transition PoreIBA
10/2014 - 12/2003
121- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
10/2014 - 08/2002
9Glucose (Dextrose)FDA LinkGeneric
01/2021 - 04/2003
8Glucagon-Like Peptide 1 (GLP 1)IBA
01/2021 - 01/2005
7Metformin (Glucophage)FDA LinkGeneric
01/2022 - 05/2008
6salicylhydroxamic acid (SHAM)IBA
01/2023 - 10/2015
6triphenyltetrazoliumIBA
01/2019 - 02/2003
5Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
12/2022 - 12/2007
5CytokinesIBA
11/2022 - 08/2010
5Proteins (Proteins, Gene)FDA Link
01/2020 - 05/2010
5Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA
01/2018 - 06/2002
5Cyclosporine (Ciclosporin)FDA LinkGeneric
01/2017 - 08/2002
5Insulin (Novolin)FDA Link
11/2014 - 04/2003
5Adenosine Triphosphate (ATP)IBA
09/2007 - 08/2002
570-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA
08/2007 - 09/2003
4AnthracyclinesIBA
06/2023 - 02/2016
4WortmanninIBA
01/2018 - 02/2003
4BradykininIBA
10/2017 - 02/2003
4LipidsIBA
11/2016 - 04/2009
4Atorvastatin (Lipitor)FDA Link
11/2011 - 02/2003
4ErythropoietinFDA Link
10/2011 - 12/2007
4AdipokinesIBA
03/2011 - 12/2007
4Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
10/2010 - 02/2003
4Protein Kinases (Protein Kinase)IBA
08/2010 - 09/2007
3Reactive Oxygen Species (Oxygen Radicals)IBA
11/2023 - 09/2007
3Biomarkers (Surrogate Marker)IBA
06/2023 - 01/2016
3BuffersIBA
02/2019 - 06/2011
3Evans Blue (Blue, Evans)FDA Link
01/2019 - 04/2005
3ChemokinesIBA
01/2019 - 09/2013
3AutacoidsIBA
08/2010 - 10/2003
3Cell Surface ReceptorsIBA
07/2009 - 10/2003
3Adenosine (Adenocard)FDA LinkGeneric
05/2009 - 09/2003
3Phosphoric Monoester Hydrolases (Phosphatases)IBA
11/2008 - 08/2002
3Mitogen-Activated Protein KinasesIBA
12/2007 - 01/2005
3Diazoxide (Hyperstat)FDA Link
08/2007 - 08/2002
2Fatty Acids (Saturated Fatty Acids)IBA
11/2022 - 04/2003
2Oxygen (Dioxygen)IBA
01/2021 - 10/2017
2Neuroprotective AgentsIBA
10/2020 - 12/2019
2LiraglutideFDA Link
12/2019 - 02/2017
2Sodium-Glucose Transporter 2 InhibitorsIBA
02/2019 - 02/2017
2CXCR4 Receptors (CXCR4 Receptor)IBA
01/2019 - 09/2013
2Caspase 1 (ICE Protease)IBA
01/2019 - 01/2018
2Doxorubicin (Adriamycin)FDA LinkGeneric
01/2018 - 11/2009
2Nitric Oxide (Nitrogen Monoxide)FDA Link
01/2018 - 02/2003
2Protein Isoforms (Isoforms)IBA
10/2017 - 05/2009
2MelatoninIBA
01/2017 - 01/2017
2GadoliniumIBA
03/2016 - 09/2011
2Brain Natriuretic Peptide (Natrecor)FDA Link
02/2016 - 05/2003
2MicroRNAs (MicroRNA)IBA
02/2016 - 01/2016
2Mitochondrial DNA (mtDNA)IBA
02/2016 - 08/2013
2Troponin T (Troponin T1)IBA
10/2015 - 10/2011
2Cyclophilins (Cyclophilin)IBA
07/2014 - 11/2011
2Peptide Hormones (Polypeptide Hormones)IBA
02/2011 - 01/2009
2LeptinIBA
10/2010 - 04/2009
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
07/2009 - 02/2003
2Purinergic P1 Receptors (Adenosine Receptor)IBA
05/2009 - 09/2003
2UrocortinsIBA
01/2009 - 10/2002
2Peptides (Polypeptides)IBA
01/2009 - 11/2007
2U 0126 (UO 126)IBA
08/2008 - 09/2007

Therapy/Procedure

40Therapeutics
11/2023 - 04/2003
20Percutaneous Coronary Intervention
11/2023 - 11/2005
9Ischemic Postconditioning
12/2022 - 08/2004
6Coronary Artery Bypass (Coronary Artery Bypass Surgery)
11/2023 - 06/2010
5Drug Therapy (Chemotherapy)
06/2023 - 06/2012
3Critical Care (Surgical Intensive Care)
11/2022 - 10/2022
3Length of Stay
12/2014 - 12/2010